CNTN5,轴突蛋白5抗体

产品编号HZ-11453R
英文名称CNTN5
中文名称轴突蛋白5抗体
别 名Contactin5; Contactin 5; Contactin-5; hNB 2; HNB 2s; NB 2; Neural recognition molecule NB 2; CNTN5_HUMAN; Neural recognition molecule NB-2; hNB-2.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 细胞粘附分子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
CNTN5,轴突蛋白5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量119kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Contactin 5 (801-900aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CNTN5,轴突蛋白5抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. This protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].

Function:
CNTN5 is a member of the immunoglobulin superfamily. Contactins mediate cell surface interactions during the development of the nervous system. CNTN5 has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons and is most likely involved in neuronal activity in the auditory system.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Expressed in brain and kidney and at very low level in placenta. Not expressed in other tissues. In brain, it is highly expressed in the occipital lobe, amygdala, cerebral cortex, frontal lobe, thalamus and temporal lobe. Expressed at moderate level in the cerebellum, substantia nigra, putamen, medulla and hippocampus. Weakly expressed in the spinal cord and caudate nucleus. Weakly or not expressed in the corpus callosum.

Similarity:
Belongs to the immunoglobulin superfamily. Contactin family.
Contains 4 fibronectin type-III domains.
Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

CNTN5,轴突蛋白5抗体Database links:
Entrez Gene: 53942 Human
Entrez Gene: 244682 Mouse
Entrez Gene: 114589 Rat
Omim: 607219 Human
SwissProt: O94779 Human
SwissProt: P68500 Mouse
SwissProt: P97527 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.